NMN vs NR: Principais diferenças
Um novo estudo oficial está aqui! Um experimento de 2025 da equipe da Northwest A&F University, publicado no Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), revelou com rigora the true health effects of NMN and NR—two NAD+ precursors that both support gut health, fight inflammation and oxidation, yet each has its own distinct strengths. After reading this, you’ll never have to struggle over which to choose again!
PARTE 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Reequilibrando a Microbiota Intestinal: Mais Bactérias Benéficas, Mais Estabilidade
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Figura 1: Efeitos da alimentação com NMN e NR na diversidade microbiana intestinal em camundongos.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Figura 2: Efeitos da alimentação com NMN e NR na diversidade microbiana intestinal em camundongos.
C: Abundância de espécies em nível de filo no grupo alimentado por NMN;
D: Abundância de espécies em nível de filo no grupo alimentado com NR
Anti-inflamatório e Antioxidante Double Boost: Protegendo a Saúde do Metabolismo aos Genes
Inflamação e danos oxidativos são causas raiz de muitos distúrbios. NMN e NR os contrapõem de ambos os lados:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Figura 3: Mapa de calor dos metabólitos diferenciais no grupo alimentado com NMN
Figura 4: Mapa de calor dos metabólitos diferenciais no grupo alimentado com NR
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Figura 5: Efeitos da alimentação com NMN e NR nos fatores inflamatórios intestinais em camundongos.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: Expressão por PCR da interleucina 6 (IL-6);
PARTE 02
Principais Diferenças: Escolher NMN ou NR para otimização precisa da saúde
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Figura 6: Estatísticas das células caliciformes no cólon de camundongo
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
PARTE 03
Choose According to Your Needs—Science Over Guesswork
Os resultados de 2025 deixam claro: NMN e NR não são substitutos, mas opções complementares. Seja seu objetivo proteger a saúde intestinal ou aumentar a vitalidade física, escolher o precursor certo do NAD+ respaldado por literatura autoritária dá à sua saúde uma dupla camada de segurança.
PARTE 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Desde 2012, a Bontac Bio é uma empresa de alta tecnologia especializada em tecnologia de biocatálise. No desenvolvimento e produção do NR Malate (NRHM), a empresa integra sua expertise única e inovação, demonstrando vantagens técnicas e de produto excepcionais.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Conformidade e Certificação: A Bontac possui certificações internacionais FSSC 22000, Self-GRAS, FDA, Kosher e HALAL, garantindo total conformidade com padrões globais desde P&D até a produção. Estudos adicionais, incluindo testes anti-fotoenvelhecimento e níveis de NAD+ com peixe-zebra, confirmaram ainda mais sua eficácia e potencial.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
PARTE 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Reequilibrando a Microbiota Intestinal: Mais Bactérias Benéficas, Mais Estabilidade
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Figura 1: Efeitos da alimentação com NMN e NR na diversidade microbiana intestinal em camundongos.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Figura 2: Efeitos da alimentação com NMN e NR na diversidade microbiana intestinal em camundongos.
C: Abundância de espécies em nível de filo no grupo alimentado por NMN;
D: Abundância de espécies em nível de filo no grupo alimentado com NR
Anti-inflamatório e Antioxidante Double Boost: Protegendo a Saúde do Metabolismo aos Genes
Inflamação e danos oxidativos são causas raiz de muitos distúrbios. NMN e NR os contrapõem de ambos os lados:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Figura 3: Mapa de calor dos metabólitos diferenciais no grupo alimentado com NMN
Figura 4: Mapa de calor dos metabólitos diferenciais no grupo alimentado com NR
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Figura 5: Efeitos da alimentação com NMN e NR nos fatores inflamatórios intestinais em camundongos.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: Expressão por PCR da interleucina 6 (IL-6);
PARTE 02
Principais Diferenças: Escolher NMN ou NR para otimização precisa da saúde
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Figura 6: Estatísticas das células caliciformes no cólon de camundongo
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
PARTE 03
Choose According to Your Needs—Science Over Guesswork
Os resultados de 2025 deixam claro: NMN e NR não são substitutos, mas opções complementares. Seja seu objetivo proteger a saúde intestinal ou aumentar a vitalidade física, escolher o precursor certo do NAD+ respaldado por literatura autoritária dá à sua saúde uma dupla camada de segurança.
PARTE 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Desde 2012, a Bontac Bio é uma empresa de alta tecnologia especializada em tecnologia de biocatálise. No desenvolvimento e produção do NR Malate (NRHM), a empresa integra sua expertise única e inovação, demonstrando vantagens técnicas e de produto excepcionais.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Conformidade e Certificação: A Bontac possui certificações internacionais FSSC 22000, Self-GRAS, FDA, Kosher e HALAL, garantindo total conformidade com padrões globais desde P&D até a produção. Estudos adicionais, incluindo testes anti-fotoenvelhecimento e níveis de NAD+ com peixe-zebra, confirmaram ainda mais sua eficácia e potencial.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
